|
Vol 57(2023) N 6 p. 1143-1164; DOI 10.1134/S0026893323060067  R.G. Goncharov1, M.G. Sharapov1* Ischemia-Reperfusion Injury: Molecular Mechanisms of Pathogenesis and Methods of Their Correction 1Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290 Russia*sharapov.mg@yandex.ru Received - 2023-04-10; Revised - 2023-05-09; Accepted - 2023-05-10 Ischemia-reperfusion is a cascade of complex and interrelated pathological processes underlying many human diseases, including such socially significant diseases as stroke, myocardial infarction, acute renal failure, etc. The present review considers modern ideas about the main biochemical and signal-regulatory processes in the cell under conditions of ischemia-reperfusion. Both generally accepted and newly developed ways of ischemia-reperfusion lesion correction aimed at different chains of this pathological process are considered. ischemia-reperfusion, oxidative stress, intracellular signaling, HIF, NRF2, NF-κB, PI3K/AKT/mTOR, hypothermia, oxidase inhibitors, H2S, antioxidants, selenium, mimetics, antioxidant enzymes |
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
