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Vol 57(2023) N 6 p. 1024-1037; DOI 10.1134/S0026893323060043  D.A. Chernyavskij1, I.I. Galkin2, A.N. Pavlyuchenkova1,2, A.V. Fedorov3, M.A. Chelombitko2,4* Role of Mitochondria in Intestinal Epithelial Barrier Dysfunction in Inflammatory Bowel Disease 1Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, 119991 Russia2Belozersky Institute of Physicochemical Biology, Moscow State University, Moscow, 119991 Russia 3Biological Faculty, Moscow State University, Moscow, 119991 Russia 4Russian Clinical Research Center for Gerontology, Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, 129226 Russia *chelombitko@mail.bio.msu.ru Received - 2023-04-10; Revised - 2023-05-26; Accepted - 2023-05-29 Inflammatory bowel disease (IBD) is widespread in industrial countries with every 20th citizen being affected. Dysregulation of the epithelial barrier function is considered to play a key role in IBD. Permeability of the intestinal epithelium depends mostly on its self-renewal potential and the condition of intercellular junctions. Mitochondria are involved in regulating various intracellular processes in addition to their energy function. Recent data implicate mitochondria in intestinal epithelial barrier regulation and IBD. Mitochondrial dysfunction is possibly one of the factors that underlie the structural abnormalities of tight junctions and the cytoskeleton in intestinal epithelial cells and decrease the self-renewal capacity of the epithelium. The barrier function of the intestinal epithelium is consequently distorted, and IBD develops. The mechanisms of these processes are still unclear and require further research. intestinal epithelium, mitochondria, inflammatory bowel diseases, reactive oxygen species, anti-oxidants |
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