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Vol 46(2012) N 2 p. 210-217; N.A. Oskina1*, U.A. Boyarskih1, A.F. Lazarev2, V.D. Petrova2, D.I. Ganov2, O.G. Tonacheva3, G.I. Lifshits1, M.L. Filipenko1 Association of Chromosome 8q24 Variants with Prostate Cancer Risk in the Siberian Region of Russia and Meta-Analysis 1Institute of Chemical Biology and Basic Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia2Altai Affiliated Department of the Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Barnaul, 656049, Russia 3Krasnoyarsk Regional Oncologic Centre, Krasnoyarsk, 660133, Russia *nattasha.o@gmail.com Received - 2011-09-12; Accepted - 2011-10-21 Compelling evidence demonstrates the importance of chromosome 8q24 as a locus of susceptibility to prostate cancer. In this work, the association of common 8q24 variants, rs6983267 and rs1447295, with a sporadic risk of prostate cancer was analyzed in the Russian population of Siberia. For this purpose, the above polymorphisms were genotyped in 393 cases and 384 control individuals. The A allele of rs1447295 was significantly associated with prostate cancer risk (OR[CI 95%] = 1.74 [1.26-2.4], p = 7.8 10-4). The common G-A haplotype of rs6983267-rs1447295 also showed association with prostate cancer risk in Russians (OR[CI 95%] = 2.03 [1.1-3.75], p = 0.02). A meta-analysis combining our data with previously published results was performed to better evaluate the association between the SNPs studied and prostate cancer risk; its results strongly supported the association for both loci (p < 10-6). Thus, our study has confirmed the association of chromosome 8q24 with a risk of prostate cancer. prostate cancer, single nucleotide polymorphism (SNP), Russian population, chromosome 8q24, meta-analysis |
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