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YearIMPACT-FACTOR
2022  1,200
2021  1,540
2020  1,374
2019  1,023
2018  0,932
2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 49(2015) N 1 p. 103-111; DOI 10.1134/S0026893315010112 Full Text

A.G. Nikitin1*, V.A. Potapov2, A.N. Brovkin1, E.Yu. Lavrikova1, D.S. Khodyrev1, M.Sh. Shamhalova3, S.A. Smetanina4, L.N. Suplotova4, M.V. Shestakova3, V.V. Nosikov1, A.V. Averyanov1

Association of FTO, KCNJ11, SLC30A8, and CDKN2B polymorphisms with type 2 diabetes mellitus

1Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies, Federal Medico-Biological Agency of Russia, Moscow, 116682 Russia
2Arkhimed Clinics of New Medical Technologies, Moscow, 129128 Russia
3Endocrinology Research Center, Moscow, 117036 Russia
4Tyumen State Medical Academy, Tyumen, 625023 Russia

*avialn@gmail.com
Received - 2014-07-28; Accepted - 2014-09-05

To test FTO, KCNJ11, SLC30A8, and CDKN2B for association with type 2 diabetes mellitus (DM), the allele and genotype frequency distributions were established for several polymorphisms of the genes. A comparison of allele and genotype frequencies between DM patients and healthy subjects implicated CKNJ11, SLC30A8, and CDKN2B, but not FTO, in the disease. The genes that affect insulin production and secretion in pancreatic β cells proved to play a main role in type 2 DM in the Russian population.

type 2 diabetes mellitus, polymorphism, genetic predisposition



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