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Vol 52(2018) N 6 p. 846-853; DOI 10.1134/S0026893318060171 Full Text

E.N. Vasilieva1*, I.G. Laptev2,3, P. V. Sergiev2,3, O.A. Dontsova2,3,4

The Common Partner of Several Methyltransferases Modifying the Components of The Eukaryotic Translation Apparatus

1Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, 119991 Russia
2Faculty of Chemistry, Moscow State University, Moscow, 119991 Russia
3Skolkovo Institute of Science and Technology, Skolkovo, 143026 Russia
4Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997 Russia

*elnvasv@gmail.com
Received - 2018-06-28; Accepted - 2018-07-16

TRM112 is necessary for the activation and stability of several methyltransferases involved in the modification of various components of the translation apparatus. This unique protein is a partner for enzymes that methylate tRNA, rRNA, and the translation termination factor. Here we review the structural and functional features of the TRM112 complexes with methyltransferases and provide, where possible, information on their significance.

methylation, translation, methyltransferase, tRNA, rRNA, translation termination factor, ribosome assembly



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