Vol 52(2018) N 6 p. 836-845; DOI 10.1134/S0026893318060055
M.S. Drutskaya1,2*, V.S. Gogoleva1,2, K.-S.N. Atretkhany1,2, E.O. Gubernatorova1,2, R.V. Zvartsev1, M.A. Nosenko1,2, S.A. Nedospasov1,2**
Proinflammatory and Immunoregulatory Functions of Interleukin 6 as Identified by Reverse Genetics1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia
2Biological Faculty, Moscow State University, Moscow, 119234 Russia
Received - 2018-06-18; Accepted - 2018-06-18
Reverse genetics approach, involving genome editing, makes it possible not only to establish the nonredundant and unique functions of genes and their products, but also to construct animal models for biomedical research. Interleukin 6 (IL-6) is an important immunoregulatory and proinflammatory cytokine that differs from many related proteins in having a rather complicated signal transduction scheme. Apart from the multiple functions of IL-6, the most relevant biological problem of recent years was establishing what cells produce IL-6, in what form IL-6 is produced, what cells are recipients of the IL-6 signal, and what are the downstream events and physiological consequences of the IL-6 signaling cascade. Because IL-6 is involved in the pathogenesis of many diseases and is a drug target, understanding the mechanisms of its normal and pathogenic effects is important for the clinics. The review summarizes the recent data available in the field.
IL-6, gp130, mouse models, experimental autoimmune encephalomyelitis, asthma, inflammation, genome editing