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Vol 52(2018) N 6 p. 799-811; DOI 10.1134/S0026893318060080 Full Text

A.V. Finkelstein1,2, S.V. Razin2,3, A.S. Spirin1,2*

Intersubunit Mobility of the Ribosome

1Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290 Russia
2Biological Faculty, Moscow State University, Moscow, 119192 Russia
3Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia

*spirin@vega.protres.ru
Received - 2018-05-24; Accepted - 2018-05-24

Ribosomes are ribonucleoprotein nanoparticles synthesizing all proteins in living cells. The function of the ribosome is to translate the genetic information encoded in a nucleotide sequence of mRNA into the amino acid sequence of a protein. Each translation step (occurring after the codon-dependent binding of the aminoacyl-tRNA with the ribosome and mRNA) includes (i) the transpeptidation reaction and (ii) the translocation that unidirectionally drives the mRNA chain and mRNA-bound tRNA molecules through the ribosomal intersubunit space; the latter process is driven by the free energy of the chemical reaction of transpeptidation. Thus, the translating ribosome can be considered a conveying protein-synthesizing molecular machine. In this review we analyze the role of ribosomal intersubunit mobility in the process of translocation.

ribosome, molecular machines, translocation, free energy, transpeptidation, rectification of Brownian motion



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