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Vol 52(2018) N 3 p. 446-452; DOI 10.1134/S0026893318030147 Full Text

E.G. Varlamova1*, M.V. Goltyaev1, J.P. Kuznetsova2

Effect of Sodium Selenite on Gene Expression of SELF, SELW, and TGR Selenoproteins in Adenocarcinoma Cells of the Human Prostate

1Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290 Russia
2Voronezh State University of Engineering Technologies, Voronezh, 394036 Russia

*1928lv@mail.ru
Received - 2017-08-02; Accepted - 2017-11-23

Selenium is an essential trace element, the deficiency of which leads to the development of several serious diseases, including male infertility, prostate cancer, etc. It has been shown that oxidative stress contributes to the progression of prostate cancer, and antioxidants such as selenium and vitamin E can significantly reduce the risk of this disease. Sodium selenite, one of the selenium compounds that induce the formation of reactive oxygen species, is considered as a potential anticancer agent. The SS concentrations that lead to a decrease in the viability of human prostate adenocarcinoma cells (line Du-145) have been selected, and the effect of sodium selenite on the expression of mRNA of the SELV, SELW, and TGR selenocysteine proteins in these cells has been analyzed.

selenium, mammalian selenocysteine-containing proteins, prostate cancer, sodium selenite



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