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Vol 51(2017) N 6 p. 788-803; DOI 10.1134/S002689331706005X Full Text

S.M. Deyev1,2, E.N. Lebedenko1*

Targeted Bifunctional Proteins and Hybrid Nanoconstructs for Cancer Diagnostics and Therapies

1Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997 Russia
2Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, 603950 Russia

*elebedenko@mail.ru
Received - 2017-03-24; Accepted - 2017-04-09

In this review, the authors' works published within the past 5 years devoted to the development of bifunctional hybrid nanostructures based on the targeting polypeptides and nanoparticles of various origin (quantum dots, nanogold, nanodiamonds, upconversion nanoparticles, magnetic and polymer nanoparticles) as modules that ensure visualization and various damaging effects on cancer cells are surveyed and the prospects of their application in theranostics and precision medicine have been contemplated.

DARPins, scFv, HER2, protein photosensitizers, riboflavin, NIR, exotoxin A, upconverting nanophosphores, nanogold, imaging, photodynamic and photothermal therapies, tumor xenografts, Biocomputing



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