JMB-HEADER RAS-JOURNALS EIMB Pleiades Publishing

RUS

             

ENG

YearIMPACT-FACTOR
2022  1,200
2021  1,540
2020  1,374
2019  1,023
2018  0,932
2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 51(2017) N 5 p. 733-739; DOI 10.1134/S0026893317050247 Full Text

O.L. Zinovieva, E.N. Grineva, M.M. Prokofjeva, D.S. Karpov, G.S. Krasnov, V.S. Prassolov, T.D. Mashkova, N.A. Lisitsyn*

Treatment with anti-cancer agents results in profound changes in lncRNA expression in colon cancer cells

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia

*niklisitsyn@yahoo.com
Received - 2017-03-22; Accepted - 2017-05-10

Using real-time RT-PCR in combination with bioinformatics, we have shown for the first time that the treatment of HCT-116 and HT-29 colon cancer cells with two anti-cancer agents (doxycycline or 3,3'-diindolylmethane) results in profound changes in the intracellular content of several lncRNAs (by up to 100 times). Since many of these RNAs are secreted by tumors into the bloodstream, the obtained results provide a basis for developing more sensitive protocols for serological monitoring of tumor relapse and metastasis, as well as for search of new anti-cancer drugs.

long noncoding RNAs, anti-cancer agents, colorectal cancer



JMB-FOOTER RAS-JOURNALS