Vol 51(2017) N 5 p. 705-711; DOI 10.1134/S0026893317050090
T.S. Frolova1,2,3*, A.V. Lipeeva1, D.S. Baev1,3, Y.A. Tsepilov2,3, O.I. Sinitsyna2,3
Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells1Vorozhtsov Novosibirsk Institute of Organic ChemistrySiberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090 Russia
2Institute of Cytology and GeneticsSiberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090 Russia
3Novosibirsk State University, Novosibirsk, 630090 Russia
Received - 2016-09-06; Accepted - 2016-12-03
Pentacyclic triterpene acids are of great interest as compounds that exhibit selective cytotoxicity against malignant tumor cells. If earlier studies were carried out mainly in cancer cells of epithelial origin, in the present work the cytotoxic effect of ursolic and pomolic acids on the primary and permanent glioma cell lines was analyzed. Both compounds are toxic to oncotransformed cells and induce apoptosis in U-87 MG line. Using molecular docking, it has been shown that Akt1 and MDM2 may be potential targets of the studied triterpene acids. It has been suggested that ursolic and pomolic acids induce apoptosis in glioma cells through inhibition of the PI3K/Akt signaling pathway, and they can be considered as potentially promising agents for the treatment of glioblastoma.
ursolic acid, pomolic acid, selective cytotoxicity, glioma, apoptosis