Vol 51(2017) N 3 p. 389-392; DOI 10.1134/S0026893317020029
T.O. Abramova1, M.A. Ryazanova1, E.V. Antonov1, O.E. Redina1*, A.L. Markel1,2
Increase in the concentration of sEH protein in renal medulla of ISIAH rats with inherited stress-induced arterial hypertension1Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090 Russia
2Novosibirsk State University, Novosibirsk, 630090 Russia
Received - 2016-04-19; Accepted - 2016-05-10
The concentration of soluble epoxide hydrolase (sEH) protein was studied in renal medulla of adult rats from hypertensive ISIAH strain and normotensive WAG strain. The sEH is a key enzyme in metabolism of epoxyeicosatrienoic acids capable of activating endothelial NO-synthase and nitrogen oxide formation, and therefore being vasodilators. An increase in the sEH protein concentration (that we found) allows one to assume that the oxidative stress is increased in the renal medulla of hypertensive rats, and the bloodflow is decreased.
soluble epoxide hydrolase, ELISA, real time PCR, arterial hypertension, renal medulla, ISIAH rat strain