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Vol 44(2010) N 5 p. 741-747;
K.A. Blagodatskikh1*, M.A. Evdokimova2, Y.V. Agapkina1, A.G. Nikitin1, A.N. Brovkin1, A.A. Pushkov1, E.G. Blagodatskikh1, O.Y.Aseycheva2, V.S. Osmolovskaya2, L.O. Minushkina2, M.S. Kochkina2, N.D. Selezneva2, E.N. Dankovtseva2, O.S. Chumakova2, T.N. Baklanova3, P.A. Talyzin3, N.E. Reznichenko3, O.P. Donetskaya4, S.N. Tereschenko5, E.S. Krasilnikova5, N.A. Dzhaiani5, E.V. Akatova5, M.G. Glezer6, A.S. Galyavich7, V.B. Zakirova7, N.A. Koziolova8, I.V. Timofeeva8, A.V. Yagoda9, O.I. Boyeva9, L.I. Katelnitskaya10, E.V. Horolets10, S.V. Shlyk10, E.G. Volkova11, M.P. Margaryan11, I.O. Guz11, V.O. Konstantinov12, N.V. Timofeeva12, B.A. Sidorenko2, D.A. Zateyshchikov2, V.V. Nosikov1

The Polymorphisms G( 174)C in IL6 Gene and G( 1082)A in IL10 Gene Are Associated with Poor Outcomes in Patients with Acute Coronary Syndrome

1State Research Center GosNIIgenetika, Moscow, 117545, Russia
2Medical Academic and Research Center, Administrative Department of the President of the Russian Federation, Moscow, 121359, Russia
3Municipal Hospital no.17, Moscow, 119620, Russia
4Clinical Hospital no.1, Administrative Department of the President of the Russian Federation, Moscow, 107143, Russia
5Moscow State University of Medicine and Dentistry, Moscow, 127473, Russia
6Sechenov Moscow Medical Academy, Moscow, 119021, Russia
7Kazan State Medical University, Kazan, 420012, Russia
8Vagner Perm State Medical Academy, Perm, 614000, Russia
9Stavropol State Medical Academy, Stavropol, 355014, Russia
10Rostov State Medical University, Rostov-on-Don, 344022, Russia
11Chelyabinsk State Medical Academy, Chelyabinsk, 454092, Russia
12Mechnikov St. Petersburg State Medical Academy, St. Petersburg, 195067, Russia

*konst.blag@gmail.com
Received - 2010-03-11; Accepted - 2010-04-30

Association between the rates of poor outcomes in the patient cohort with acute coronary syndrome and polymorphisms G(-174)C in the IL6 gene and G(-1082)A in the IL10 gene were determined. In total, 1145 patients hospitalized for coronary artery disease to cardiological hospitals of Moscow, St. Petersburg, Kazan, Chelyabinsk, Perm, Stavropol, and Rostov-on-Don were examined. The mean observation period was 9.10 + 5.03 months (maximal, 18 months). Analysis of the survival of the patients with acute coronary syndrome that carried allele A has demonstrated that the presence of IL10 gene polymorphism G(-1082)A is associated with more frequent poor outcomes as compared with GG genotype. The survival time to endpoint for the carriers of GA and AA genotypes was 11.68 + 0.67 months versus 12.69 + 0.65 months for the carriers of GG genotype in IL10 gene ( χ2 = 4.13, p = 0.042). As for the IL6 genepolymorphism G(-174)C, survival rate analysis did not detect any significant association with the risk for poor outcome. However, joint analysis of these polymorphisms in both genes has demonstrated that characteristic of the patients with acute coronary syndrome that carry GG genotype of IL6 gene and GA and AA genotypes of IL10 is a higher rate of poor outcomes (time to endpoint, 11.01 + 1.24 months) as compared with the carriers of IL6 gene CC and CG genotypes and IL10 gene GG genotype (time to endpoint, 13.28 + 0.83 months ( χ2 = 10.23, p = 0.017). These data suggest that the genes IL6 and IL10, whose products are involved in the control of inflammatory response, play an important role by increasing the probability of poor outcomes in the  patients with acute coronary syndrome.

Hordeum vulgare, real-time PCR, microgravity, gene expression, antioxidant defense



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