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Vol 44(2010) N 5 p. 728-733; O.Y. Makarycheva1, E.Y. Tsareva1,2, M.A. Sudomoina1,2, O.G. Kulakova1,2, O.V. Bykova3, N.V. Gol'tsova3, L.M. Kuzenkova3, A.N. Boiko2, O.O. Favorova1,2* Linkage and Association of Proinflammatory Cytokines Genes IL-6, IFNG and TNF with Multiple Sclerosis 1Russian Research-and-Production Center, Ministry of Health, Moscow, 121552 Russia2Russian State Medical University, Moscow, 117437 Russia 3Science Center for Children Health, Russian Academy of Medical Sciences, Moscow, 119991 Russia *olga.favorova@gmail.com Proinflammatory cytokines interleukin-6 (IL-6), interferon- (IFNg) and tumor necrosis factor (TNF) play an important role in the pathogenesis of multiple sclerosis. Based on the published data concerning the effects of the SNPs G(-308)A of TNF, A(+874)T of IFNG, and G(-174)C of IL-6 on the production of these cytokines, we investigated the relation of these polymorphisms with multiple sclerosis. Linkage and association of alleles of these genes with multiple sclerosis were analyzed by transmission disequilibrium test. In a group of 104 nuclear families of Russian ethnicity, the TNF* (-308)A allele was more frequently transmitted from healthy heterozygous parents to affected children (p = 0.01). Linkage/association of IFNG and IL-6 alleles with multiple sclerosis was not detected. Thus, the data obtained indicate that TNF is involved in susceptibility to multiple sclerosis in Russians. human, multiple sclerosis, genotyping, proinflammatory cytokines, tumor necrosis factor, interleukin-6, interferon- , TNF, IL-6, IFNG, allelic polymorphism, TDT, functional genomics |
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