2014  0,718
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 51(2017) N 2 p. 205-215; DOI 10.1134/S0026893317020066 Full Text

V.M. Blinov1, V.V. Zverev1, G.S. Krasnov1,2,3, F.P. Filatov1,4*, A.V. Shargunov1

Viral component of the human genome

1Mechnikov Research Institute of Vaccines and Sera, Moscow, 105064 Russia
2Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia
3Orekhovich Research Institute of Biomedical Chemistry, Moscow, 119121 Russia
4Gamaleya Research Center of Epidemiology and Microbiology, Moscow, 123098 Russia

Received - 2015-12-27; Accepted - 2016-04-27

Relationships between viruses and their human host are traditionally described from the point of view taking into consideration hosts as victims of viral aggression, which results in infectious diseases. However, these relations are in fact two-sided and involve modifications of both the virus and host genomes. Mutations that accumulate in the populations of viruses and hosts may provide them advantages such as the ability to overcome defense barriers of host cells or to create more efficient barriers to deal with the attack of the viral agent. One of the most common ways of reinforcing anti-viral barriers is the horizontal transfer of viral genes into the host genome. Within the host genome, these genes may be modified and extensively expressed to compete with viral copies and inhibit the synthesis of their products or modulate their functions in other ways. This review summarizes the available data on the horizontal gene transfer between viral and human genomes and discusses related problems.

Virus, horizontal gene transfer, cell receptor