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Vol 50(2016) N 6 p. 799-811; DOI 10.1134/S0026893316060030 Full Text

I.V. Alekseenko*, A.I. Kuzmich, V.V. Pleshkan, D.V. Tyulkina, M.V. Zinovyeva, M.B. Kostina, E.D. Sverdlov

The cause of cancer mutations: Improvable bad life or inevitable stochastic replication errors?

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997 Russia

*irina.alekseenko@mail.ru
Received - 2016-03-13; Accepted - 2016-03-24

Despite substantial progress in understanding the mechanisms of carcinogenesis and fighting oncology diseases, cancer mortality remains rather high. Therefore, there is a striving to reduce this mortality to the level determined by endogenous biological factors. The review analyzes the mutations that lead to cell malignant transformation and describes the contribution that self-renewal of adult tissues makes to tumorigenesis. Cancer progression is considered as a development of a complicated system where cells mutate, evolve, and are subject to selection. Cancer paradoxes are described in conclusion.

mutation, cancer, tumor evolution, driver genes, self-renewal



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