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Vol 44(2010) N 4 p. 546-551; S.A. Golenkina1, A.Y. Goltsov5, I.L. Kuznetsova1, A.P. Grigorenko1,5, T.V. Andreeva5, D.A. Reshetov1, S.S. Kunizheva5, L.I. Shagam1, I.Y. Morozova1, I.V. Goldenkova-Pavlova1, H. Shimshilashvili1, A.O. Vyacheslavova1, G. Faskhutdinova2, A.E. Gareeva2, A.G. Zainullina2, E.K. Khusnutdinova2, V.P. Puzyrev3, V.A. Stepanov3, A.V. Kolotvin4, L.M. Samokhodskaya4, N.D. Selezneva5, S.I. Gavrilova5, E.I. Rogaev1,5,6 Association of the Polymorphic Markers G(--455)A in the FGB Gene and C(--1654)T in the PROC Gene with Hereditary Predisposition to Severe Ischemic Heart Disease in Patients with Histories of Acute Coronary Syndrome 1Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991 Russia2Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences, Ufa, 450054 Russia 3Institute of Medical Genetics, Tomsk Research Center, Siberian Division, Russian Academy of Medical Sciences, Tomsk, 634050 Russia 4OOO University Medicine, Moscow, 119192 Russia 5Mental Health Research Center, Russian Academy of Medical Sciences, 117152 Russia 6University of Massachusetts Medical School, Department of Psychiatry, Worcester, 01604 US *rogaev@vigg.ru Received - 2009-11-30; Accepted - 2010-01-28 To date, three gene mutations are known which cause familial forms of Alzheimer's disease: PSEN1, PSEN2, and APP; APOE gene polymorphism is a strong risk factor for Alzheimer's disease. We have evaluated allele and genotype frequency distribution of rs11136000 polymorphism in the clusterin (CLU) gene (or apolipoprotein J, APOJ) in populations of three Russian regions and in Alzheimer's disease patients. Genome-wide association studies in samples from several European populations have recently revealed the highly significant association of CLU gene with AD (p = 8.5) Alzheimer's disease, association analysis, polymorphism, apolipoprotein J (APOJ), clusterin (CLU) |
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