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Vol 46(2012) N 1 p. 1-10; V.B. Teif1*, A.V. Shkrabkou2, V.P. Egorova2, V.I. Krot3 Nucleosomes in Gene Regulation: Theoretical Approaches 1Bioquant and German Cancer Research Center , Heidelberg, 69121, Heidelberg2M. Tank Belarusian State Pedagogical University, Minsk, 220050, Belarus 3Belarusian State University, Minsk, 220030, Belarus *vladimir.teif@bioquant.uni-heidelberg.de Received - 2011-03-24; Accepted - 2011-04-28 This work reviews current theoretical approaches of biophysics and bioinformatics for the description of nucleosome arrangements in chromatin and transcription factor binding to nucleosomal organized DNA. The role of nucleosomes in gene regulation is discussed from the molecular-mechanistic and biological points of view. In addition to classical problems in this field, actual questions of epigenetic regulation are discussed. The authors selected for discussion what seem to be the most interesting concepts and hypotheses. Mathematical approaches are described in a simplified language to attract attention to the most important directions of this field. nucleosome, chromatin, lattice models, competitive binding, transcription factors |
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