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Vol 50(2016) N 4 p. 510-520; DOI 10.1134/S0026893316040026 Full Text

N. Ambartsumian*, M. Grigorian**

S100A4, a link between metastasis and inflammation

Department of Neuroscience and Pharmacology, Faculty of Health and Medical Science University of Copenhagen, Copenhagen, Denmark

*ambartsumian @sund.ku.dk
**grigorian@sund.ku.dk
Received - 2016-02-01; Accepted - 2016-02-01

Chronic inflammation is acknowledged to be a hallmark of neoplasia - both in cancer initiation and metastasis progression. Here we summarise data suggesting that S100A4 is а trigger of the cascade events that establish an inflammatory milieu and provide a potent flame for primary tumour growth and especially for its metastatic dissemination. The S100A4 protein belongs to the S100 superfamily of small Ca2+-binding proteins. Well established function of S100A4 is associated with induction and promotion of tumour metastasis. However, this protein is also involved in the pathogenesis of major human non-communicable diseases (NCD), such as autoimmune diseases, fibrosis, and other disorders. Therefore, we suggest that S100A4 is a common pro-inflammatory factor involved in the pathogenesis of diverse NCD including cancer.

carcinogenesis, metastasis, inflammation, non-communicable diseases, S100A4 protein



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