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Vol 45(2011) N 1 p. 66-73;
S.V. Tillib*

"Camel Nanoantibody" is an Efficient Tool for Research, Diagnostics and Therapy

Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia

*tillib@genebiology.ru
Received - 2010-08-16; Accepted - 2010-08-16

This short review provides an introduction to the rapidly developing field of generation and utilization of "camel nanoantibodies" (or "nanobodies"). The term "nanoantibody" or "nanobody" was given to single-domain variable fragments of special type of antibodies that naturally exist (in addition to classical types of antibodies) in blood of Camelidae family animals and in some chondrichthyan fishes. The existence of very efficient technology of nanobody generation and some very useful characteristic features promise a big potential for their use in immunobiotechnology and medicine.

recombinant antibodies, single-domain antibodies, camel antibodies, VHH, nanobody, nanoantibody, phage display



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