JMB-HEADER RAS-JOURNALS EIMB Pleiades Publishing

RUS

             

ENG

YearIMPACT-FACTOR
2022  1,200
2021  1,540
2020  1,374
2019  1,023
2018  0,932
2017  0,977
2016  0,799
2015  0,662
2014  0,740
2013  0,739
2012  0,637
2011  0,658
2010  0,654
2009  0,570
2008  0,849
2007  0,805
2006  0,330
2005  0,435
2004  0,623
2003  0,567
2002  0,641
2001  0,490
2000  0,477
1999  0,762
1998  0,785
1997  0,507
1996  0,518
1995  0,502
Vol 42(2008) N 5 p. 668-680;
E.I. Rogaev1,2,3, S.A. Borinskaya2,4, D.V. Islamgulov3,5, A.P. Grigorenko1,3

Human microRNA in norm and pathology

1Mental Health Research Center, Russian Academy of Medical Sciences, Moscow, 113122, Russia
2Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia
3Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA, 01604, USA
4Institute of Cognitive Research, Russian Research Center Kurchatov Institute, Moscow, 123182, Russia
5Institute of Biochemistry and Genetics Ural Research Center, Russian Academy of Sciences, Ufa, 450054, Russia
Received - 2008-05-21; Accepted - 2008-05-21

MicroRNAs (miRNAs) are a class of regulatory RNAs that control gene expression at the posttranscriptional level. Binding to the target mRNA, miRNA suppresses its translation and/or induces its degradation. Although started relatively recently, studies of miRNAs have already shown that miRNAs are essential for switching the gene expression programs during embryo development and sustaining the normal cell function in the adult organism. Alterations of miRNA expression pattern and/or efficiency of mRNA binding seem to be as important in pathology as better known structural variations of proteins. The key role of miRNA has been demonstrated for the balance of cell proliferation, differentiation, and programmed death in several common diseases. The review considers the specifics of the miRNA-mediated regulation of gene expression and its role in normal and pathological development of muscle, immune, and nervous systems. Evidence is given for the involvement of miRNA in neurodegenerative and mental disorders.

microRNA, development, differentiation, tissue specificity, cancer, cardiovascular diseases, neuropsychiatric diseases



JMB-FOOTER RAS-JOURNALS