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Vol 42(2008) N 4 p. 558-566; A.R. Galimov1,2, A.A. Kruglov1,2, N.L. Bolsheva1, O.Yu. Yurkevich1, D.Ja. Liepinsh3, I.A. Mufazalov1,2, D.V. Kuprash1, S.A. Nedospasov1,4 Chromosomal localization and molecular organization of the human genomic fragment containing the TNF/LT locus in transgenic mice 1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia2Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, 119899, Russia 3Center for Cancer Research, NCI-Frederick, Frederick, Maryland, 21702, USA 4Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 199992, Russia Received - 2007-12-14; Accepted - 2008-03-04 The molecular organization, copy number, and chromosome location of the human TNF/LT transgenes were studied in the genomes of two transgenic mouse strains. One strain proved to carry two transgene copies arranged head-to-tail and detected on chromosome 8 by karyotyping. The other strain had one transgene copy observed on chromosome 5. The strains provide a model for studying the physiological functions of the tumor necrosis factor and lymphotoxin. TNF, LTα, human transgene |
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