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Vol 42(2008) N 2 p. 213-216; I.A. Goncharova1, E.V. Beloborodova2, M.B. Freidin1, E.I. Beloborodova2, G.E. Chernogoruk2, V.P. Puzyrev1,2 Association of immune system gene polymorphisms with quantitative traits pathogenetically important for chronic virus hepatitis 1Institute of Medical Genetics, Tomsk Research Center, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, 634050, Russia2Siberian State Medical University, Tomsk, 634050, Russia Received - 2007-03-12; Accepted - 2007-10-11 The IL4 C(-590)T, IL4RA Ile50Val, and TNF G(-308)A polymorphisms were tested for association with quantitative traits important for chronic virus hepatitis, including the levels of IL4, IL10, IL12, TNF-α, fibronectin, collagenase, the proteinase inhibitor, macroglobulin, and free and protein-bound (PBO) oxyproline. Allele A of the TNF G(-308)A polymorphism was associated with a lower TNF-α production by mononuclear cells, a higher production of IL4 and IL12, and a lower PBO level. The genotype CT of the IL4 C(-590)T polymorphism was associated with a high PBO level. chronic virus hepatitis, genetics of infectious diseases, genetic polymorphism, cytokine genes |
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