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Vol 48(2014) N 1 p. 99-104; DOI 10.1134/S0026893313060095 Full Text

I.G. Nikitina1, E.Yu. Sabirova1, O.N. Solopova2, S.A. Surzhikov1, E.N. Grineva1, V.L. Karpov1, N.A. Lisitsyn1, S.F. Beresten1*

A New Immuno-PCR Format for Serological Diagnosis of Colon Cancer

1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia
2All-Russia Scientific Center of Molecular Diagnostics and Treatment, Moscow, 117638, Russia

*sberesten@gmail.com
Received - 2013-05-29; Accepted - 2013-06-25

A new immuno-PCR format based on the detection of CDH17 membrane protein in serum exosomes is proposed. Using the technique described, it was possible to distinguish between serum specimens obtained from healthy donors and colon cancer patients. The results suggest that the new technique may enable the serological diagnosis of colon cancer in high-risk groups.

tumor exosomes, immuno-PCR, DNA reporter, homoprimer, colon cancer
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