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Vol 46(2012) N 3 p. 335-348;
K.V. Glebova1, A.V. Marakhonov1, A.V. Baranova1,2, M.Y. Skoblov1*

Therapeutic siRNAs and Nonviral Systems for Their Delivery

1Research Centre for Medical Genetics, Russian Academy of Medical Sciences, Moscow, 115478 Russia
2School of Systems Biology, George Mason University, Fairfax, USA

*mskoblov@generesearch.ru
Received - 2011-09-12; Accepted - 2011-10-10

Gene-directed therapy with small interfering RNA (siRNA) has a tremendous potential and will undoubtedly occupy one of the leading positions among other therapeutic methods in the future. The lack of efficient and targeted delivery vectors delays a successful implementation of this method in medicine. To develop such systems, one needs a comprehensive insight into the interactions of siRNAs, its delivery systems, and an organism. The review covers the properties of therapeutic siRNAs and nonviral systems for their delivery.

RNA interference, siRNA, siRNA delivery



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