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Vol 48(2014) N 4 p. 583-589; DOI 10.1134/S0026893314040049 Full Text

N.E. Gogoleva*, L.V. Shlykova, V.Y. Gorshkov, A.G. Daminova, Y.V. Gogolev

Effect of Topology of Quorum Sensing-Related Genes in Pectobacterium atrosepticum on Their Expression

Institute of Biochemistry and Biophysics, Kazan Research Center, Russian Academy of Sciences, Kazan, 420111, Russia

*negogoleva@gmail.com
Received - 2014-03-21; Accepted - 2014-03-28

In prokaryotic genomes, the neighboring genes are often located on the complementary DNA strands and adjoin each other by their 5'- or 3'-ends, or even overlap with their open reading frames. It was suggested that this gene topology has a functional purpose of regulating their expression. For the genes that overlap by their coding 3'-end encoding regions, this assumption has not been confirmed experimentally. In a broad group of bacteria that belong to proteobacteria, this convergent gene arrangement is typical for functionally connected quorum sensing-related genes "I" and "R" which encode synthases of autoinducers, such as N-acyl homoserine lactones and their sensors, respectively. In the present study on the example of overlapping quorum sensing-related genes of plant pathogenic bacterium Pectobacterium atrosepticum SCRI1043, expI, and expR, it was shown that the topology of these genes determines the regulation of their expression.

quorum sensing, regulation of gene expression, regulatory RNA, analysis of N-acyl homoserine lactone production, Pectobacterium atrosepticum SCRI 1043, convergent transcription



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